October 5, 2021, from WalesbiologyTechnology companies Jellagen and Copner Biotechnology have joined forces to strive for new bio-ink technology extracted from jellyfish collagen with advanced precisionsoftwareCombined, and they claim that this collaboration is unprecedented.It is reported that the commercial R&D from WalesinvestAfter SMART Cymru received £123,724 in funding, the two companies are looking to use Jellagen’s proprietary type 0 collagen bio-ink and Copner Biotech’s advanced algorithm software to improve3D bioprintingCompatibility, repeatability, and accuracy. Professor Andrew Mearns Spragg, the founder and chief scientific officer of Jellagen, said: “We are very happy to work with Jordan Copner and his Copner Biotech team.Medical treatmentExciting cooperation has been established at the forefront of technological innovation in tissue engineering. “
△Jellagen three-dimensional scaffold creates a three-dimensional cell culture environment, enabling cells to maintain their in vivo morphology, behavior and reactivity in an in vitro model system. Photo from Jellagen.
Jellyfish Collagen Biological Collection
Jellagen was established in 2015 with the purpose of developing and commercializing marine-derived collagen for use in medical and scientific research fields.3D bioprintingapplication. The company is seeking to establish sustainable sources of key biomaterials that do not pose the environmental and human health risks that traditional collagen sources do.The company has been committed to developing its next-generation type 0 collagen bio-ink, which is derived from jellyfish collagen, and hopes to establish partnerships with medical institutions to study the treatment of this material for skin diseases and tissue reconstruction. The collagen in Jellagen’s biomaterials is extracted from Rhizostoma Pulmo, an ancient large jellyfish commonly found in the Irish Sea. According to the company, type 0 collagen has been shown to promote anti-inflammatory tissue responses, produce fewer side effects than traditional collagen extracted from mammals, and demonstrate good compatibility and repeatability for bioprinting applications .
Jellagen is currently selling a series of type 0 collagen products for research, and is also developing products for treatment and medical equipment.
clinical
Grade formula. Their company’s current products include collagen-based gels, scaffolds, and collagen-coated petri dishes.
△Jellagen’s bioprinting products include petri dishes coated with type 0 collagen, suitable for cell culture research purposes. Photo from Jellagen.
Establish a “paradigm shift” in bioprinting
According to Jellagen and CopnerBiotech, their new partnership may change3D bioprintingMarket, VerifiedMarket Research’s Global3D bioprintingThe market report predicts that by 2028, its market value will reach 1.4 billion pounds.
From the future cooperation of the two, we will see the combination of Jellagen’s type 0 collagen bio-ink and Copner Biotech’s advanced algorithm software to improve3D bioprintingThe accuracy of the process.
Copner Biotechnology was established last year with the goal of creating a new software platform to manufacture products for applications in the 3D cell culture market (such as cancer research and tissue engineering). Since then, it has developed a novel software operating platform for designing cell culture scaffolds that are conducive to oxygen and nutrient gradients, and was awarded the GHP International Life Science Innovation Award earlier this year.
On October 1, Copner Biotechnology filed an application with the British Intellectual Property Office for a patent for the design and manufacturing workflow of using its cell adhesion to scaffold technology to produce 3D biological scaffolds. Looking ahead, as part of a new partnership with Jellagen, Copner Biotech will seek to further develop and commercialize its software through the large-scale manufacturing of polymer cell scaffolds and other bioprinting products.
“This is a huge and exciting scientific collaboration between Copner Biotech and Jellagen, which also reflects3D bioprintingGloballymedicineThe field of research is becoming more and more important,” said Jordan Copner, the founder and CEO of Copner Biotech. “Our cooperation is an innovative move to advance biomedical engineering! “
△ SEM image of the three-dimensional scaffold and L929 fibroblast filling provided by Copner Biotech; the sample is provided by Dr. Alex Bryant. Picture courtesy of Dr. Bethan R Thomas/Copner Biotech.
Bioprinting inspired by the ocean
along with3D bioprintingContinuing to receive more and more attention and development, scientists are increasingly seeking to copy or imitate materials and processes that exist in nature. These materials and processes exhibit ideal characteristics that cannot be obtained by artificial means. In particular, the development of biological sinks and bioprinting applications from the ocean has aroused great interest, and a series of research breakthroughs have recently appeared.
For example, researchers at Rutgers University, inspired by the adaptive cells found in squid, cuttlefish, and octopus,3D printingA disguised soft robot, and scientists at Yamagata University have developed a3D printingThe actuator can form the basis of a jellyfish-like soft robot.
In June, scientists at Northwestern University discovered a rare iron mineral in a mollusk tooth that resembles a “floating meatloaf”, and set out to use this discovery to develop suitable3D printingBio-ink to imitate the strength, hardness and connection characteristics of a mollusk stylus. Recently, researchers from the Pacific Northwest National Laboratory have developed a new seaweed-based bio-ink that can be combined with fine micron-sized pigment powders to produce bright colors suitable for artistic applications.
From the perspective of the development of bio-inks, the layered structure of limestone has been used in the design3D printingThe microneedle patch, and the biomimetic cell structure with unique energy absorption capacity has been developed based on the skeleton of the cuttlefish3D printing.In other places, the lobster shell pattern even constitutes3D printingThe foundation of concrete structure design.
△JellaGel is the next generation of jellyfish collagen hydrogel, used for in vitro cell culture and tissue engineering. Photo from Jellagen.
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