China3D printingNet, June 22, the biotechnology expert Pixelbio has developed a new type 3D printingMolecular biochips may accelerate the pace of clinical genetic testing.
Using Formlabs 3D printers and Black Resin, Pixelbio has been able to create a new “HuluFISH” sensor device that can simultaneously detect multiple different genetic codes using multicolor probes. By doing so, the company has successfully reduced costs and delivery times, while producing a flexible clinical tool that can now help accelerate cancer diagnosis and the development of other drugs and vaccines.
“Thanks to the high precision and printing speed of Form 3, we can use it to print tubes smaller than 1 mm into a small space,” said Liu Sheng, Pixelbio’s development director. “We also found that once the design is correct, we can produce the required parts quickly and on a large scale, but the cost of each product will be very expensive and not necessarily suitable for our needs. [使用现有技术]. “
Use Pixelbio’s 3D printed chip to identify the color to mark molecules.
Pixelbio’s molecular chip contains multiple labeled probes that can identify up to seven different genes in a single reaction. The picture comes from Formlabs.
Harnessing the potential of “FISH”
First introduced in the 1960s, in situ hybridization has become a common method for identifying the location of specific nucleic acids, DNA, and RNA in tissues, cells, and chromosomes. Generally speaking, this technique involves the use of chemical or radioactive probes, which are usually used to detect cancer cells in cytology specimens. It effectively enables clinicians to achieve early disease prognosis and treatment.
Based on this method, these scientists are now increasingly turning to fluorescence in situ hybridization or “FISH” technology, through which they attach colored markers to certain genes to improve the visibility of the microscope, but Even if the method is capable of single-molecule detection, its existence is limited to the identification of one gene at a time.
To solve this problem, Pixelbio developed “HuluFISH”, a flexible 3D printed biochip that allows clinicians to track a large number of genes at the same time. The company is marketing as the “first personalized multi-smFISH solution”, effectively providing production chips as a service, which enables customers to quickly order from a series of marker genes and receive corresponding molecular equipment for testing.
The Form 3 3D printer installed in the Pixel Bio R&D laboratory.
Pixelbio’s 3D printed biochip has great potential as a disease diagnosis tool. The picture comes from Formlabs.
Advanced DNA detection biochip
Using current biochips with a 0.8-1.2 mm channel, it is possible to evaluate samples by laser identifying genes, but such devices usually need to be adjusted according to the composition of the liquid being tested. More importantly, given the various shapes and sizes of probes, the specifications of biochips are always changing, so a prototyping process that may take months to complete is required.
In contrast, since adopting Formlabs’ technology, Pixelbio has been able to create HuluFISH internally, thereby reducing related production costs and delivery time. Due to its inherent low opacity, black resin has also proven to be an ideal choice for chip manufacturing, and the company is now using this material to accelerate the development of its next-generation products.
Elsewhere in its laboratory, Pixelbio also deployed Form 3 and Formlabs’ Clear Resin to produce precision-fitted closures to protect the liquid inlet of its chips, and to move forward, it now intends to continue 3D at its Hamburg factory Print HuluFISH and develop a unique microarray chip at the R&D center in Heidelberg.
In terms of the future potential of HuluFISH, the flexibility of its built-in probes makes it an ideal choice for identifying different COVID-19 strains, analyzing their progress, and advancing the development of enhanced vaccines. With this in mind, Pixelbio is participating in NIH’s Rapid Diagnostic Acceleration (RADxSM) program, which aims to develop improved COVID testing technology through the program.
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