China3D printingNet February 23 news,biology3D printingThe manufacturer of the machine, Readily3D, has announced its participation in the European ENLIGHT project.
Readily3D will work with a number of research institutions and companies in the region in3D printingThe living model of the human pancreas plays a role in improving the testing of diabetes drugs. Specifically, the company will sign a contract to become the official bioprinter manufacturer for the project to adjust its proprietary non-contact tomography lighting technology to meet the special needs of the pancreatic tissue structure.
The Horizon 2020 Innovation Fund has awarded the ENLIGHT project a four-year grant totaling 3.6 million euros. The project aims to produce the first working pancreas model within three years. The models themselves will be printed at UMC Utrecht and EPFL, the latter being the first to use volumetric printing in biomanufacturing applications in 2019. ETH Zurich and the University of Naples will provide the specialized stem cells needed to complete the project.
Damien Loterie, CEO of Readily3D, said: “We are very happy to be a member of the ENLIGHT project and work with our partners to promote the cutting-edge field of biomanufacturing.”
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Human fluff” alt=”Bio by Readily
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Human fluff” width=”620″ height=”414″ />
By Readilybiology3D printingHuman fluff. Photos taken by Readily3D.
Paving the way for high-speed bioprinting
In order to achieve the three-year goal, ENLIGHT researchers have two obstacles to overcome. The first is the development of the bioprinter itself, which will be based on Readily3D’s existing Tomolite 3D printingmachine.If everything goes according to plan, then the final product will be able to perform “lightning speed” on the human cell structure.3D bioprinting.
traditional3D printingIt may take several hours for the machine to manufacture centimeter-level structures layer by layer, and Readily3D’s volumetric printing technology will be able to achieve this goal in less than 30 seconds. According to reports, the speed of the printer is particularly important, because as the printing time increases, the survival rate of living cells will drop sharply.
Paul Delrot, CTO of Readily3D, explained: “With its fast build speed, low light dose and sterile build environment, our tomography bioprinter will open applications that were previously inaccessible in the biomanufacturing field.”
Once the bioprinter can3D printingIn the living pancreas model, the second obstacle will be the addition of signal molecules to the structure, which will determine how the cells behave under external stimuli. This will essentially rebuild cell function at the level of human organs, allowing researchers to use this structure as a test pancreas for diabetes research without the need for animal testing.
Professor Riccardo Levato, a biomanufacturing researcher at UMC Utrecht and coordinator of ENLIGHT, added: “With the patient’s cells, the practitioner can reconstruct the diseased tissue. Later, laboratory tests can be conducted to determine which drug candidate is most effective. This way. It can save patients from searching for a long time, and has unpleasant side effects, save treatment costs, and provide the best care for a single patient.
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machine” alt=” Tomolite by Readily3D
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Machine” width=”620″ height=”413″ />
Tomolite by Readily3D 3D bioprintingmachine. Photos taken by Readily3D.
Why focus on diabetes drug research?
Researchers believe that focusing on diabetes and3D printingThe choice of pancreatic tissue is a very deliberate choice. Except for asthma, diabetes is the most common chronic disease among children, which has certain social significance for the project. In addition, despite continuous advances in medicine, the development of new diabetes treatments (except insulin therapy) is still lagging behind, which urgently requires drug development. When talking about how to expand the possibility of cancer and other diseases, Levato said, “The pancreas is our’proof of principle’. Once we have successfully established a life model of the pancreas and actually tested diabetes drugs with it, it will prove that new organisms The effectiveness of printing technology. Then, we can use these technologies more widely. In principle, you can use it to make living models of various tissues.”
Readily3D biologically stains 3D blood vessels. Photos taken by Readily3D.
With similar goals, researchers at the University of Stuttgart and Robert Bosch Hospital recently announced the development of a novel3D printingOrganization platform, which can replace animal testing in clinical trials. With the support of 3.8 million euros from Baden-Württemberg, Germany, scientists tried to build an in vitro tissue model to test the efficacy of cancer drugs.
Elsewhere, scientists from Tsinghua University have already conducted3D bioprintingThe bioprinting of the brain-like tissue structure can nourish the nerve cells of rats. After several weeks of in vitro cultivation, the research team was able to cultivate the entire complex neural network that can respond to external stimuli, paving the way for new drug research.
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