China3D printingOn the 6th and 5th of the net, recently, the first teamTeam of scientistsIn their recently published paper “Used in Drug Applications3D printingIn Manufacture of Artificial Blood Vessels, the researchers not only discussed the risk of cardiovascular disease as the leading cause of mortality in the elderly, but also discussed the adoption of3D printingA new method of making artificial blood. In the future, it can improve the quality of life of patients and reduce the risk of cardiac arrest.
From the current point of view, artificial blood vessels (ABV) have posed many challenges, and researchers have been looking for other blood vessel support methods.In this study, researchers tried to use polymer materials and bioceramic nanoparticles3D printingA new artificial biological composite blood vessel, the thermoplastic polyurethane (TPU) used is composed of nanocrystalline hydroxyapatite (HA) nano powder.
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Artificial blood vessel to treat cardiovascular disease” alt=”researcher
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Artificial blood vessel to treat cardiovascular disease” />
use3D printingThe principle design and structure of the two-component bio-nanocomposite ABV of the machine, HA powder and TPU polymer
As early as 1912, researchers began to use a combination of metal and glass tubes to create artificial arteries for dogs in need of heart surgery. Later, more advanced research showed that researchers were able to create a polymer matrix for arterial replacement. Drug therapy has always been the main method for treating patients with cardiovascular disease (CVD).
As researchers began the process of making artificial veins, many considerations were given to appropriate biocompatible materials. The filament is created in three steps:
1. Prepare nanocrystalline HA powder from bovine bone, grind for 10 hours, and then heat to 800-850°C for 3 hours to purify the material.
2. Grind the TPU polymer into smaller particles, then mix with HA powder concentration.
3. Put the filament3D printingIn order to make artificial veins, the diameter of each artificial vein is 6 mm.
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Artificial blood vessel to treat cardiovascular disease” alt=”researcher
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Artificial blood vessel to treat cardiovascular disease” />
ABV is designed with CAD software; a) multiple branches, b) two branches, and c) single branch using physical working software
The researchers pointed out that although the shortcomings of TPU are abrasion resistance and some “lack of transparency” in different solvents, the advantages are more obvious:
high strength
Biocompatibility
Non-sticky
High polarity
“In the high-energy ball mill, TPU biopolymer is mixed with various concentrations of HA power (0, 2.5, 5 and 7.5 wt%),” the researchers explained. “Then, the mixed composite powder is inserted into the extruder at a specific heating rate. Then, the result is extracted with the homogenized TPU-HA filament and inserted3D printingIn the machine.
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Artificial blood vessel to treat cardiovascular disease” alt=”researcher
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Artificial blood vessel to treat cardiovascular disease” />
a) Design a double-branch ABV, b) Design solid engineering software and the method of the container in the ABV model in the simplified 3D software, c) the top of the SEM image and d) by3D printingHorizontal view of the SEM image constructed by the machine (aperture: 50-100 microns)
After evaluating the mechanical and biological properties, the researchers found that the biodegradability of the polymer has changed and affected the mechanical properties. It was found that ABV can function “multiple times” in the human body and survive high blood pressure and pulmonary vein movement.
“…The new biotechnology ABV is compact, flexible, and anticoagulant. At the same time, they also have a nanotechnology-based heart palpitations adaptation system and the loading of specific microscopic molecules in the adhesive. Using atomic and molecular level analysis Materials and nanotechnology enable these thorns to enter the magnetic core (stem cells). When the stem cells are absorbed, they cover the entire inner surface of the stem and become endothelial cells. Researchers say that using these polymer materials can be transplanted in human ABV , Thereby helping to provide nutrition for body tissues.
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Although there are still challenges in the use of artificial veins, the researchers said that they believe that “vascular replacement is imperative,” especially for those with smaller veins.
According to the research results, the combination of analytical model and experimental evaluation can be used to simulate the micromechanical behavior of arteries. It is also worth noting that the porosity of blood vessels significantly affects the shear stress and elastic modulus of veins. In this regard, the research results show that the blood rheological behavior has a significant influence on the change of shear stress.
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Artificial blood vessel to treat cardiovascular disease” alt=”researcher
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Artificial blood vessel to treat cardiovascular disease” />
By immersing in a) acidic solution3D printingBiological test results of the prepared artificial bio-nanocomposite materials, b) sample fixation in saline solution, c) SBF solution for 21 days
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