China3D printingNet February 19th, biomedical engineers at Rutgers University in New Jersey have developed a method for3D printingBio-ink, which can build a scaffold that supports human tissues. What is important is that the stiffness of the stent can be controlled according to the mixture of inks used, so that it can be applied to different types of tissues for repair or replacement.
The researchers detailed the modified form of hyaluronic acid and polyethylene glycol to form a strong gel suitable for use as a scaffold.
“We want the mixture to have the right characteristics, not the ink color of the inkjet printer, which is suitable for specific cells to expand, differentiate and reshape the scaffold into a suitable tissue.”Department of Biomedical Engineering, Rutgers University-University of New Brunswick School of EngineeringSenior author David I. Shreiber explained.“We focused on the firmness of the junction between the gel and the scaffold so that cells can attach to it.”
3D printingsystem. Image courtesy of Rutgers University/Madison Godesky. “alt=” of bio-ink based on hyaluronic acid3D printingsystem. Image courtesy of Rutgers University/Madison Godesky. “width=”620″ height=”802” />
Bio-ink based on hyaluronic acid3D printingsystem. Image courtesy of Rutgers University/Madison Godesky.
What is hyaluronic acid?
Hyaluronic acid is a natural molecule located in many tissues of the human body. A transparent, viscous substance is found in the skin, connective tissue and eyes. The human body contains a large amount of hyaluronic acid, which is naturally produced by the skin to maintain its moisture content. So it has also become a common ingredient in skin care products.Researchers at the University of California, Los Angeles (UCLA) also use this substance for3D printingCreated a viable bio-ink.
The properties of hyaluronic acid make it very suitable for making customized stents, but it lacks the durability to be used as a support structure. The team of researchers strengthened hyaluronic acid by combining hyaluronic acid with polyethylene glycol (a polyether compound), which has a variety of applications from industrial manufacturing to medicine. Through a chemical reaction, the bound substances help to form an enhanced gel, suitable as a scaffold to support tissue growth.
Shreiber, together with the lead author of the study, Madison D. Godesky, conceived the3D printingThey will use a mixture of hyaluronic acid and polyethylene glycol as the cartridges in the system. 3D printingThe machine will use this cartridge to print a gel stent or support structure to help human tissues grow.
In addition, the researchers also assume that other cartridges with different cell and ligand characteristics are included to serve as binding sites for the cells. In this way, depending on the type of organization that needs to be supported,3D printingThe machine will produce a gel scaffold with the correct number of stiffness, cells and ligands.This allows scientists to adjust3D printingThe stiffness of the tissue scaffold: “Both stiffness and binding sites provide important signals to the cell,” Godesky added. “It is particularly different from previous studies in that the hardness and ligand can be independently controlled by the combination of inks.”
support3D printingTissue growth in
In the field of regenerative, precise and personalized medicine, the subject of bioengineering organizations has received widespread attention. Product development; and basic research. 3D bioprintingThe emergence of technology supports the latest developments on this subject to produce scaffolds or temporary structures for tissue growth.
3D printing
The printer head on the machine deposits functionalized polymer ink layer by layer from the needle head” alt=”solvent casting
3D printing
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Solvent casting3D printingThe printer head on the machine deposits functionalized polymer ink layer by layer from the needle. The picture comes from Lehigh University.
For example, researchers at Lehigh University in Pennsylvania recently proposed a new3D printingA platform that can regenerate multiple tissues using a spatially functionalized scaffold.In addition, a team from the Utrecht University Medical Center (UMC) and the Swiss Federal Institute of Technology Lausanne (EPFL) also developed a volume3D bioprintingThe craft, which is inspired by visible light projection, can form a free-form organizational structure.3D printingOEM 3D Systems chose to cooperate with Israeli bioprinting material developer CollPlant to create tissue and scaffold bioprinting solutions for third-party partners. Through cooperation, the two companies aim to combine their respective expertise to accelerate breakthroughs in the biomedical industry.
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