Recently, from Rice UniversitybiologyEngineers use3D printingAnd smart biomaterials, creating a new type of insulin that can produce insulin for patients with type 1 diabetesImplants. This breakthrough is the result of a three-year collaboration between researchers and the Juvenile Diabetes Research Foundation. The researchers used insulin-producing beta cells made from human stem cells to create an implant that can sense and regulate blood sugar levels and respond with the correct amount of insulin within a specific time.
Researchers Omid Veiseh and Jordan Miller have been working on this project for more than ten years. Veiseh said that to reproduce the normal functioning of the pancreas, one needs to haveBlood vessel. The pancreas has many blood vessels and cells, which are organized in a specific way, and the researchers hope to print out the corresponding tissues that exist in nature.
Type 1 diabetes is an autoimmune disease that causes the pancreas to stop producing insulin. Insulin is a hormone needed to control blood sugar levels. Approximately 1.6 million people in the United States suffer from type 1 diabetes, and more than 100 cases are diagnosed every day. To control the disease, it needs to be managed by insulin injections, but it has been considered difficult to manage insulin injections stably during daily diet, exercise and other activities.
The researchers’ goal is to prove that their implants can properly regulate blood sugar levels in diabetic mice for at least six months. To do this, they need to design beta cells that can quickly respond to changes in blood sugar. Ideally, insulin-producing cells are no more than 100 microns away from blood vessels.They pass advanced3D bioprintingTechnology and host-mediated vascular remodeling combine prevascularization.
This combination gives each implant several opportunities to fuse with the host. The insulin-producing cells in the implant will be protected by a hydrogel formulation that has been shown to effectively encapsulate cell processing methods in bead-sized spheres. Their pores are small enough to prevent the cells inside from being attacked by the immune system, while at the same time large enough to allow nutrients to enter and insulin to flow out of the cells.
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