Scientifically use SLA 3D printing technology to develop equipment to treat bladder diseases

China3D printingNet December 23, researchers and pharmaceuticals from the School of Pharmacy of University College London (UCL)3D printingExpert FabRx has developed a novel3D printingA device that can deliver drugs to the bladder for a sustained period of time.
Researchers used stereolithography (SLA) to create a device for intravesical treatment-administering drugs to the bladder through a catheter-to provide an alternative to oral medications to treat severe bladder diseases.
Researchers believe that this development can provide a revolutionary method for personalized drug delivery.


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Manufacturing process of the intravesical device” alt=”Used to create
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Used to create3D printingThe manufacturing process of the intravesical device. The picture comes from the “Materials Science and Engineering” magazine.

3D printingDrug delivery device

Drug delivery device3D printingThe influence of its geometry is a topic of increasing research, and this topic will continue to see innovative developments.
Earlier this year, global engineering and technology company Renishaw (Renishaw) concluded a clinical study investigating the safety and safety of its nerve infusion drug delivery device and brain dopamine neurotrophic factor (CDNF) as a treatment for Parkinson’s disease performance.At the same time, researchers in the United Kingdom and the United States have developed a3D printingA device that has a remotely controllable system that can use an integrated macro-magnetic field to deliver drugs on demand.

Elsewhere, researchers from Zhejiang University and Montfort University have3D printingA multi-layer drug delivery device that can deliver multiple drugs to different parts of the gastrointestinal system has been developed, and a miniature drug delivery device capable of delivering payloads through blood vessels has been developed.3D printingMicro robots.Developed by ETH Zurich, and3D printingIt has been developed as a coating technology that can be used to tailor the drug release rate for specific patients in Greece and Italy.



Renishaw’s drug delivery device. Picture from Renishaw.

Treat bladder disease

During the research, the scientists used SLA and an elastic resin to create two bladder devices, one is solid and the other is hollow. They are designed to be inserted into the bladder through a urethral catheter. Before printing, the resin was loaded with three drug loadings of lidocaine hydrochloride, a drug commonly used to treat cystitis and bladder pain.
The device can change its shape to pass through the catheter, showing good resistance to compressive and tensile forces, and once moved into the body, once the external force is removed, it can maintain its original shape. 3D printingThe device also showed acceptable blood compatibility and remained in the bladder until removed through the catheter.
In terms of drug release, studies have shown that the complete release of lidocaine from the hollow device can be completed within four days, while the solid device can continue to release the drug for up to 14 days.

According to the researchers, the drug release profile of the proof-of-concept bladder device is comparable to other intravesical devices, but this manufacturing method is simpler, more personalized, and cost-effective. This study is SLA 3D printingNew opportunities are provided in the manufacture of implantable bladder drug delivery systems, because the device may be suitable for the treatment of other bladder diseases, such as overactive bladder and bladder cancer.

3D design of hollow (left) and solid (right) bladder devices (arrows indicate hollow spaces). The picture comes from Materials Science and Engineering.

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