China3D printingNet February 24th, scientists from McMaster University and University of Waterloo passed3D printingA real-time model was developed that can replicate the effects of smoking marijuana on human lungs.
By loading epithelial cells into the “In vitro Exposure System” (IVES) and exposing them to cannabis, the research team has been able to accurately map the body’s adverse reactions to recreational drugs. After the initial success, the researchers are now open source their monitoring equipment in order to conduct more extensive research.
Canadian researchers3D printingIVES equipment.
Researcher’s3D printingThe IVES device (shown in the picture) has proven that weeds are harmful to the smoker’s immune system. The picture is from the ERJ Open Research Journal.
Although our lungs are often in contact with bacteria and viruses, the human body has formed a strong immune response that can prevent us from getting sick. The epithelial cells that cover our respiratory tract are an important part of this defense. They produce mucus and antiviral cytokines. When destroyed by diseases such as asthma, they become dysfunctional and cause breathing difficulties for affected patients.
According to Canadian scientists, smoking marijuana constitutes a similar “lung attack” because it causes symptoms such as coughing, wheezing, and chest tightness. Therefore, when many people are considering legalizing them for medical purposes, in addition to informing government policies, an accurate understanding of the effects of the smoke pot is essential to identify potential warning signs.
In vitro test models have become an important tool in tobacco smoke research, but due to their cost, inaccuracy, and lack of accessibility, they are rarely used in equivalent cannabis studies.In order to overcome this problem, the scientists therefore decided to carry out the novel IVES system3D printing, The purpose is to make non-professional laboratories use it as much as possible.
Researchers tested its device by making it “smoked” cannabis. The picture is from the ERJ Open Research Journal.
3D printingRobot lung
The team uses Formlabs Form 2 3D printingThe machine manufactured a four-chambered lung-like IVES with two inlets, four outlets and four chamber covers. Theoretically, the working principle of the system is that before the smoke and dust are discharged, the smoke is “inhaled” through an air inlet, and then it is distributed to four chambers (each chamber is equipped with a battery Plug-in).
In order to actually test their new machine, the scientists chose to use a three-way valve and syringe to roll up some research-grade cannabis oil, illuminate and connect to IVES. Once the robot’s lungs “smoke” the joints, the researchers evaluated the viability of its epithelial cells and found that its own immune function was severely damaged.
Given that previous research has linked breathing difficulties and barrier disorders, the research team believes that this evidence suggests that lighting is harmful to the lungs. The researchers also compared their cytokine levels with those of patients with smoking disorders, and found that casual pot users are more likely to suffer from respiratory diseases such as throat inflammation.
Although the scientists finally admitted that further parameter tests were needed to verify their results, they believed that their instrument was successful. In fact, the research team believes that their method can be used in a variety of toxicological studies, from combination and nebulization analysis to assessing the impact of pathogens on the immune system.
Bioprinting and lung transplantation
While the Canadian team is taking preventive measures against lung diseases, it is developing3D bioprintingConsiderable progress has also been made in alternatives.
After studying the potential of bioprinting organs in the past four years, 3D Systems recently announced a breakthrough in the development of its solid tissue scaffold. The company, in collaboration with United Therapeutics, has been able to create a system for manufacturing vascular tissue, called “print-to-perfusion.”
Similarly, United Therapeutics also partnered with Isreali bio-printing company CollPlant to transform a tobacco factory into a “kidney production line.” The two companies strengthened their partnership last year and signed a new agreement in which they promised to enter mass production at the plant. kidney.
On a smaller scale, a team from the U.S. Department of Veterans Affairs (VA) is using3D printingChips, they can support faulty organs. Ultimately, the researchers aim to create a device that constitutes an “artificial lung” to help regulate the healthy carbon dioxide intake of poor patients.
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