China3D printingOn the seventh day of the Chinese New Year, researchers at the University of Stuttgart and Robert Bosch Hospital are developing a novel3D printingOrganization platform, which can replace animal testing in clinical trials.
As part of a 3.8 million euro project approved by the German state of Baden-Württemberg, scientists are trying to build an in vitro tissue model to test the efficacy of cancer drugs.The joint team believes that using3D bioprintingMachines and simulation data can now create skin-like microfluidic structures, if any, it can produce more realistic predictions of tumor progression than before.
Professor Roland Kontermann from the University of Stuttgart said: “If we can screen out the best drug candidates in an in vitro culture system, we can greatly reduce the number of laboratory animals used for final preclinical testing. This will completely replace animal testing. De-novo and computer simulation models will provide great potential in the future.”
3D bioprinting
To be used in cancer drug testing” alt=” Scientists based in Stuttgart are trying to
3D bioprinting
For cancer drug testing” width=”385″ height=”269″ />
Scientists based in Stuttgart are trying to perform cell structures3D bioprinting, To be used in cancer drug trials. The picture comes from the University of Stuttgart.
End animal experiment
Although there is no doubt about the importance of studying deadly diseases (such as cancer), the importance of the large number of tests performed on animals each year has greatly diminished. In Germany alone, about 3 million small animals, from birds to cows, are tested every year, but only 13% of the tests are related to disease treatment.
In fact, basic research requires 47% of all German animal testing, while the other 18% is used for education, training or breeding purposes. Given that the cruel and reliable arguments run counter to practice, a lot of research has been done on synthetic alternatives, but so far, none of them have been fruitful.
Organ-on-chip devices have shown special prospects in this field. Scientists at Harvard University3D printing“Heart on a chip”, a team at the Autonomous University of Madrid has developed a blood vessel replication device. However, despite these advances, there is still a need to develop a more robust organic platform to better reproduce the response of living tissue.
3D bioprinting
Skin sample” alt=”Poeitis
3D bioprinting
Skin sample of “width=”620″ height=”432” />
Poeitis 3D bioprintingSkin samples.
Biotech companies like Poeitis are now developing3D printingThe organization (shown in the picture) has been around for some time. Photo by Poeitis
In essence, the 3.8 million euro Southwest Germany program has established a network of state-level universities, each of which is studying different ways to improve animal welfare. In the “3R-US” part of the project, scientists in Stuttgart are trying to develop an ex vivo cancer test model, but so far, the initial progress has been tricky.
Although it has been proven that the cancer cells in the petri dish can be tested, the active ingredients can be fed directly and effectively to them, which cannot accurately reflect the distribution process of the human body. Even if mice are used as an in vitro substitute, their immune systems will be different, so it is necessary to create a novel solution.
To overcome these problems, the 3R-US team adopted a three-pronged approach to develop real-time 3D models: in vitro, innovation and computer simulation.Now, scientists will use3D bioprintingThe machine produces larger customized and nutrient-rich cell structures that can produce more decisive test results.
According to Michael Heymann of the University of Stuttgart, these printed tissues have tiny “Lego-like building blocks” that can be assembled into real tumors in the body. In the end, the team conducted experiments on these cell-based structures, aiming to generate enough data to build a computer model to more accurately simulate the drug distribution.
Currently, the scientists are only at the beginning of a five-year project, and they intend to establish a close knowledge-sharing partnership to create synergy between biotechnology and medical technology expertise.
biology3D printingSoft tissue model
Although it is still challenging to reshape the behavior of organic soft tissue realistically, many developments have been reported in the past year.Researchers at Tsinghua University have successfully performed brain-like tissues3D bioprinting, So as to be able to respond to external stimuli. Although these cells have finally been shown to form neural networks, they have actually been removed from the brains of experimental mice, which is somewhat contrary to what the Stuttgart research team tried to achieve.
Several recent research and development projects have also produced novel bioprinting materials that may prove essential to the development of this technology. For example, scientists at Texas A&M University developed a “NICE” 3D printingBiological ink, compared with the previous formula, it has higher stability.
Similarly, engineers at Rutgers University have created a new type of bio-ink made from living cells that can be used3D printingScaffold to promote the growth of human tissues. In the future, the Rutgers team’s goal is to combine its biomaterials with other materials to develop skin-like structures with customized application-specific characteristics.
China3D printingNet compile article!
(Editor in charge: admin)
0 Comments for “Scientists develop a novel 3D printed tissue platform to replace clinical animal testing”