China3D printingNet August 23, researchers from Georgia Institute of Technology and Hanyang University in South Korea have developed an aerosol jet for wireless blood flow monitoring3D printingbiological sensor.
The team used a novel AJP technology to3D printingImplantable and stretchable electronic system. In this way, the wireless circuit can be maintained, the reading distance can be enhanced, and the blood flow in the brain can be monitored for aneurysm treatment.
Implantable wireless monitoring equipment
Wearable technology refers to smart electronic devices that can be worn or implanted in the body. 3D printingNew wearable devices have been implemented, such as electronic second skins and smart textiles. In addition, in combination with soft materials, stretchable and flexible devices such as biosensors have been developed.
The functions of these sensors depend to a large extent on their wireless monitoring capabilities, which were previously implemented by rigid circuits. However, according to researchers, rigid circuits cause incompatibility with soft tissues or blood vessels.
Rigid electronic devices based on metals and plastics have a huge risk of thrombosis and flow interruption in highly contoured blood vessels and are used to monitor hemodynamics[血流动力学].
Manufacturing implantable sensors with aerosol jet printing
In order to solve the shortcomings of traditional manufacturing technology, AJP technology is introduced to produce wireless implantable sensors. This technology enables faster, more reliable manufacturing and scalable manufacturing through direct printing, digital design and optimized control.
In this study, the researchers developed a novel AJP method for the development of wireless scalable electronic devices. Their biosensor uses polyimide as the dielectric layer and bottom support layer, which is directly combined with a soft elastomer.The process starts with the high precision of the four alignment layers3D printing, Where the ink is composed of biocompatible silver nanoparticles and hybrid polyimide (PI).
Then use a small amount of soft elastomer to connect the sensor to the medical cradle. This seamless integration process allows the sensor to be consistent with the bracket, with a high degree of flexibility and stretchability. The resulting low-profile device can be deployed through conventional catheterization procedures.
AC) Diagram and image of AJP deposition of PI using a pneumatic nebulizer implanted in an aneurysm model. D) A cross-sectional SEM image showing the multilayer sensor structure. E) SEM image of AgNP after printing (left) and sintering process, showing clusters (right). F) X-ray diffractometer characterization of sintered AgNP on glass slides. Image courtesy of Georgia Institute of Technology/Advanced Science.
Wireless monitoring of hemodynamics
For the implanted wireless problem, the researchers adopted an inductive coupling method with no circuit design. The readout method applies the principle of inductive coupling between the sensor coil and two external coils in the flow diverter system to record transient signals.
After completing and optimizing the sensor system, an in vivo experiment was performed. The performance of the best sensor coil for wireless detection of resonance frequency through air, salt water and meat was studied. The maximum reading distance through the meat is 6 cm, which reaches the range of brain hemodynamic monitoring. The sensor’s flow rate monitoring capabilities were then tested in a human neurovascular model with high profile and stenosis.
The current limitation of this research is to integrate the implantable coil with the stent and sensor system to achieve a complete implantable package. Now, the team is developing methods to integrate implantable induction coils with existing stents and flow sensors.
Schematic diagram of a battery-free wireless hemodynamic monitoring system with an implantable flow sensor and two external antenna coils
China3D printingOriginal article on the net, please give back to the link for reprinting!
(Editor in charge: admin)
0 Comments for “Scientists develop implantable aerosol bio 3D printed sensors that can wirelessly monitor blood flow”