China3D printingNet January 27th, scientists at the University of New South Wales (UNSW) have developed a new technology that can3D printingA bone-like structure containing living cells, which will have potential applications in bone tissue engineering applications, disease modeling, and drug screening.
Most importantly, this method can achieve in situ reconstruction of bone and cartilage defects by extruding ceramic-based ink directly onto the affected area. According to Associate Professor Kristopher Kilian, there is no other technology for this feat so far. accomplish.
Kilian and Dr. Iman Roohani of the School of Chemistry at the University of New South Wales jointly developed this breakthrough technology, which for the first time facilitated the printing of cell-filled “bones” at room temperature.
“This is a unique technique that can produce a structure that closely mimics bone tissue,” Roohani said. “It can be used in clinical applications for in-situ repair of bone defects, such as defects caused by trauma, cancer or a large amount of tissue removed.”
3D printingMachine and a gel-like “bath” containing living cells to print bone-like structures” alt=”Scientists have worked out how to use3D printingMachine and a gel-like “bath” containing living cells to print bone-like structures” width=”620″ height=”437″ />
Scientists have worked out how to use3D printingMachine and a gel-like “bath” containing living cells to print bone-like structures. Picture from UNSW.
Ceramic Biology3D printing
Kilian and Rohaani’s new technology is called Ceramic Omnidirectional Bioprinting in Cell Suspension (COBICS), which uses3D printingThe machine deploys a new ceramic-based ink made of calcium phosphate to create a bone-like structure, which can harden the water within a few minutes.
Roohani explained: “The ink uses the setting mechanism to convert the inorganic ink into mechanically interlocked bone apatite nanocrystals by locally nano-crystallization of its components in an aqueous environment. In other words, the structure it forms is chemically It is similar to bone building blocks. The ink is formulated in a way that makes the transformation fast in a biological environment, non-toxic, and only starts to transform when the ink is exposed to body fluids, thus providing sufficient working time for the end user (such as a surgeon) “
When this ink is combined with collagen containing living cells, bone-like tissue can be produced in situ.The process can occur at room temperature, making it compatible with other3D printingThe imitation bone technology is different.In addition, living cells can become3D printingThe fact that it is part of the structure, rather than using high-temperature furnaces and irritating chemicals in the laboratory before adding living cells, makes the new method even more unique.
“The coolest thing about our technology is that you can squeeze it directly into a place with cells, such as a cavity in a patient’s bone.” Kilian said. “We can directly access bones with cells, blood vessels, and fat, and print out bone-like structures that already contain living cells in this area. There is currently no technology that can do this directly.”
3D printing
“alt=” Dr. Sara Romanazzo is going to use COBICS technology to perform
3D printing
“width=”620″ height=”437” />
Dr. Sara Romanazzo is going to use COBICS technology to perform3D printing. Picture from UNSW.
A new way to repair bone tissue
According to scientists, many surgeons and medical technology manufacturers have already expressed interest in this method, and Kilian believes it will open up a new way of treating and repairing bone tissue.
He said: “This progress has really paved the way for many opportunities that we believe can prove transformative-from using ink in the laboratory to model diseases on bones, as a bioactive material for tooth restoration, to guiding The patient’s bone reconstruction, I imagine that one day, a patient who needs a bone transplant can walk into the clinic to image the anatomy of the bone, and then convert it to3D printingThe machine then uses its own cells to print directly into the cavity.
This has the potential to completely change current practices, reduce patient suffering and ultimately save lives. “
According to China3D printingWang understands that the next step for scientists is to conduct in vivo tests in animal models to observe whether living cells in the structure that mimic bones continue to grow after being implanted in bone tissue.
Research progress of bioprinting bones
In recent years,3D printingBiological structure has become the focus of many research projects and programs, especially in the fields of tissue engineering and regenerative medicine.New bio-inks are constantly being developed for these applications and will3D printingCombined with technologies such as biomaterial engineering and stem cell biology to create a wider range of customizable bone graft materials.
Last year, researchers at Oregon Health and Science University (OHSU) studied3D printingHow the Lego-style “bone bricks” healed broken bone tissue, while another collaborative research project explored3D bioprintingHow the nanocomposite scaffold promotes bone formation.Elsewhere, Skoltech scientists used the functional representation model (FRep) to simulate3D printingMethods of personalizing ceramic bone implants.
Recently, a research team at Delft University of Technology used their own specially designed extrusion-based device to make temporary bone implants using biodegradable porous iron. The next phase of their research involves injecting nano-bioceramics to promote bone growth and integrating antibacterial agents to reduce the risk of infection.
China3D printingNet original article!
(Editor in charge: admin)
0 Comments for “The University of New South Wales develops 3D printable bone-like structures containing living cells”