China3D printingNet October 21st, every year, global traumatic brain injury (TBI) affects an average of 69 million people. Although this number is less than one percent of the global population, it is enough to attract the attention of researchers and companies that try to alleviate the pain related to injuries, which are usually caused by falls, sports injuries, and traffic accidents. of.In the United States, it is one of the main causes of death and disability of children and young people. So many biotechnology companies have sprung up through biological3D printingTechnology to solve many common diseases and diseases. Since 2016, one of them has been developing advanced stem cell-based solutions to deal with neuronal damage, especially for TBI and concussion.
New York-based Qrons has gone further in innovative research after announcing an agreement with Dartmouth College in New Hampshire, which obtained an exclusive global license to develop innovative 3D printable biocompatible materials for treatment Penetrating brain injury, etc.
This agreement, signed on October 2, enables Qrons to use a method called3D printingThe patented 3D process based on mechanically interlocking molecular materials as part of its 3D printable implants to treat penetrating brain injuries. Qrons has also signed a sponsorship research agreement with Dartmouth to promote the licensing and ownership of other intellectual property rights, and the company’s research team has worked closely with the inventors of the licensing 3D process to develop innovativeCan3D printing, Advanced biocompatible materials.
Chenfeng Ke is currently the head of the Dartmouth Ke functional materials group laboratory, which is dedicated to storage/separation and3D printingSynthesis and application of applied polymeric materials.According to the laboratory, the research program involves organic synthesis, crystal engineering, polymer synthesis, material characterization and3D printingThe focus is on the design of non-covalently assembled polymer materials.
“We are very happy to work with Qrons and continue to develop3D printingFunctional smart hydrogel to treat traumatic brain injury. “Qrons Scientific Advisory Board member Ke said.
Nowadays, the current treatment methods to help patients recover function after TBI are mainly to reduce secondary injuries, mainly in hospitals or specialized treatment centers for rehabilitation. It usually requires physical therapists and professional experts to help patients relearn how to walk, talk, and perform other daily tasks. Qrons claims that this treatment can partially reduce further damage, but it is almost impossible to heal the brain.
At Qrons, researchers integrate 3D printable custom scaffolds with innovative, engineered mesenchymal stem cells (MSC) for brain damage, and use a multidisciplinary approach to treat this highly complex disease to regenerate patients. Damaged organization. The company suggested that these genetically modified MSCs provide a mechanism for secreting a continuous stream of neuroprotective agents and nerve regeneration agents to drive the TBI repair mechanism. These drugs can prevent further neuronal damage and have the potential to stimulate neurons to migrate to the damaged site, regenerate axons and regenerate brain tissue.
Qrons already has two candidate products for the treatment of TBI, both of which integrate proprietary, modified MSC and smart synthetic materials. QS100 is a damage-specific3D printingYes, implantable MSCs synthetic hydrogel for the treatment of penetrating brain injury, while QS200 is an injectable MSCs synthetic hydrogel for the treatment of diffuse injuries (commonly called concussion).
Obtaining the exclusive global authorization of 3D printable materials in the field of human and animal health will enhance the company’s research level, allowing further innovation in niche areas.
Qrons co-founder and product leader Ido Merfeld said: “The intellectual property covered by the license will help us advance the treatment of penetrating brain injury. We believe in combining Qrons’ proprietary hydrogels with customizable3D printingCombination of functions is an innovative method for the treatment of traumatic brain injury, which has limited therapeutic effects. “
According to China3D printingThe network understands that Qrons is one of 111 bioprinting companies in the world and is rapidly researching new technologies that can promote nerve recovery. In the past three years, they have signed a research agreement with Ariel University in Israel to develop and commercialize products for neuron tissue regeneration and repair, completed the first in vivo animal experiment of QS100, and are about to start clinical trials. Pre-experiment.
[图片：Qrons和达特茅斯学院]
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